CALL FOR PAPERS Comparative Genomics Molecular characterization of an inward rectifier channel (IKir) found in avian vestibular hair cells: cloning and expression of pKir2.1
نویسندگان
چکیده
Manning J. Correia, Thomas G. Wood, Deborah Prusak, Tianxiang Weng, Katherine J. Rennie, and Hui-Qun Wang Departments of Otolaryngology and Neuroscience and Cell Biology, Department of Human Biological Chemistry and Genetics, Sealy Center for Molecular Science, Department of Otolaryngology, University of Texas Medical Branch; Departments of Otolaryngology and Physiology and Biophysics, University of Colorado Health Sciences Center, Denver Colorado; and Sealy Center For Environmental Health and Medicine, University of Texas Medical Branch, Galveston Texas, 77555-1063
منابع مشابه
Molecular characterization of an inward rectifier channel (IKir) found in avian vestibular hair cells: cloning and expression of pKir2.1.
A fast inwardly rectifying current has been observed in some of the sensory cells (hair cells) of the inner ear of several species. While the current was presumed to be an IKir current, contradictory evidence existed as to whether the cloned channel actually belonged to the Kir2.0 subfamily of potassium inward rectifiers. In this paper, we report for the first time converging evidence from elec...
متن کاملPG-00096-2004.R1 Molecular Characterization of an Inward Rectifier Channel (IKir) found in Avian Vestibular Hair Cells: Cloning and Expression of pKir 2.1
A fast inwardly rectifying current has been observed in some of the sensory cells (hair cells) of the inner ear of several species. While the current was presumed to be an IKir current, contradictory evidence existed as to whether the cloned channel actually belonged to the Kir 2.0 subfamily of potassium inward rectifiers. In this paper, we report for the first time converging evidence from ele...
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The electrophysiological properties of developing vestibular hair cells have been investigated in a chick crista slice preparation, from embryonic day 10 (E10) to E21 (when hatching would occur). Patch-clamp whole-cell experiments showed that different types of ion channels are sequentially expressed during development. An inward Ca(2+) current and a slow outward rectifying K(+) current (I(K(V)...
متن کاملThe function and molecular identity of inward rectifier channels in vestibular hair cells of the mouse inner ear.
Inner ear hair cells respond to mechanical stimuli with graded receptor potentials. These graded responses are modulated by a host of voltage-dependent currents that flow across the basolateral membrane. Here, we examine the molecular identity and the function of a class of voltage-dependent ion channels that carries the potassium-selective inward rectifier current known as I(K1). I(K1) has bee...
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To understand the function of specific proteins in sensory hair cells, it is necessary to add or inactivate those proteins in a system where their physiological effects can be studied. Unfortunately, the usefulness of heterologous expression systems for the study of many hair cell proteins is limited by the inherent difficulty of reconstituting the hair cell's exquisite cytoarchitecture. Expres...
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